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Table 6 Methylation, expression analysis of Batch230 focusing only on thyroid-cancer associated genes.

From: A novel analysis strategy for integrating methylation and expression data reveals core pathways for thyroid cancer aetiology

 

Batch230

 

DMR(FDR)

DE (FDR)

FDRs Combined

Methylation Change (percentage)

RAP1GAP

9.85E-04

4.42E-10

1.28E-11

-15.75%

TIMP3

-

-

-

-28.98%

DAPK

2.61E-03

2.38E-06

1.23E-07

24.97%

SLC5A8

-

-

1.03E-03

-3.96%

RARB

-

7.41E-03

2.67E-03

-3.22%

TSHR

2.98E-03

-

7.10E-03

-9.23%

RASSF6

2.59E-04

-

1.54E-03

-37.42%

CDKN2A

-

6.15E-05

1.22E-04

3.38%

MLH1

-

-

-

-1.34%

FN1

-

1.86E-09

1.27E-09

-33.47%

FOXE1

-

-

-

1.17%

HGF

-

-

-

-14.98%

KRT19

-

4.26E-11

1.64E-10

-33.47%

LGALS3

8.55E-03

1.27E-13

3.85E-14

-11.78%

MET

-

1.13E-17

7.35E-18

-46.44%

RET

-

1.22E-03

4.33E-04

-18.49%

KISS1R

-

2.84E-05

3.77E-05

-4.81%

ADAMTS5

-

3.53E-03

8.71E-04

27.62%

HOXB4

-

-

-

-3.01%

TCL1B

3.50E-03

-

-

-35.18%

NOTCH4

-

-

9.04E-03

-12.10%

RASSF1

-

-

-

16.56%

PPARG

-

3.04E-03

1.21E-03

-2.92%

ALK

-

3.27E-09

9.25E-10

-2.57%

NTRK3

-

-

-

-2.15%

  1. Batch230 Results showing Differential Methylation (DMR), Differential Expression (DE), Combination of Differential Methylation and Differential Expression Significances (FDRs Combined) and Methylation Change in %. Only the values with Differential Expression and Differential Methylation Significances below 0.01 are shown on the table. FDR>0.01 are shown as blank. Moreover, methylation change >15% are shown as bold. Combining methylation and expression values greatly improves detecting thyroid-associated-genes as significantly altered.