Mononucleosome read phasogram. Read phasogram is defined as histogram of distances between reads mapped to the same strand of human genome and demonstrated on panel A. For the calculation of mononucleosome read phasogram only reads that are coupled into fragments with length less than 250 are taken into account. As one can see, the mononucleosome read phasograms built for two different cfDNA samples correlate with each other while this pattern is not observed in leukocyte DNA sample. Panel B demonstrates the correlation of distance between peaks.