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Table 1 Association of epigenetic marks and DNA fragmentation patterns (statistical significance)

From: Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

  K562 Huvek Nhek
  cfDNA1 cfDNA2 leukocyte DNA cfDNA1 cfDNA2 leukocyte DNA cfDNA1 cfDNA2 leukocyte DNA
H3k36me3 + +   + + + + + +
H3k4me2   + +       
H3k4me3 + + +       
Pol2b + +   + +   + +  
Ezh2     +      
H2az      +   + +  
H3k09me3     + + + + + +
H3k27ac   +        +
H3k27me3 +   +   +    +  
H3k4me1 + + + + +     +
H3k79me2 + +   + + + + + +
H3k9ac   +       +  
H4k20me1 +    + +   + +  
  1. Association of epigenetic marks and nucleosome fragmentation pattern in cfDNA (1 and 2 for the 1st and 2d patient respectively) and nuclear DNA from leukocytes used as control. Following the peak calling for cfDNA and nuclear DNA comparison with epigenetic marks peaks obtained from ENCODE project was performed and p-values were calculated. Threshold of 0.05 was used to define statistically significant correlations, which were pointed by '+' in the respective cell. Cells respective to the statistically non-significant correlations were left empty.