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Table 1 Knockout effect values R s T of 8 top target genes on expression of objective genes involved in "apoptotic process" GO category.

From: Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain

Brain structures

UBC *

RAC1 *

PTPN11

CDC42 *

FYN *

LAT2

CTNNB1 *

GRB2

Whole brain**

105.0 / 0.95

48.4 / 0.44

31.3 / 0.28

29.3 / 0.27

27.5 / 0.25

26.5 / 0.24

26.3 / 0.24

24.3 / 0.22

Cerebellum

110.2 / 1.00

50.8 / 0.46

30.2 / 0.27

32.6 / 0.30

30.0 / 0.27

26.2 / 0.24

29.9 / 0.27

26.5 / 0.24

Pons

104.5 / 0.95

49.3 / 0.45

31.3 / 0.28

32.6 / 0.30

27.0 / 0.25

28.7 / 0.26

25.0 / 0.23

22.9 / 0.21

Thalamus

102.5 / 0.93

49.8 / 0.45

31.8 / 0.29

32.5 / 0.29

28.0 / 0.25

27.4 / 0.25

26.3 / 0.24

23.2 / 0.21

Hypothalamus

103.1 / 0.94

48.9 / 0.44

30.8 / 0.28

31.6 / 0.29

27.2 / 0.25

27.5 / 0.25

28.1 / 0.25

23.5 / 0.21

Basal ganglia

104.2 / 0.95

48.5 / 0.44

33.1 / 0.30

28.7 / 0.26

26.6 / 0.24

28.3 / 0.26

26.9 / 0.24

24.0 / 0.22

Amygdala

103.8 / 0.94

47.2 / 0.43

31.9 / 0.29

29.1 / 0.26

28.0 / 0.25

27.1 / 0.25

27.6 / 0.25

24.1 / 0.22

Hippocampus

103.8 / 0.94

51.2 / 0.46

31.8 / 0.29

31.2 / 0.28

29.3 / 0.27

26.4 / 0.24

28.3 / 0.26

25.6 / 0.23

Cingulate gyrus

105.7 / 0.96

46.9 / 0.43

30.8 / 0.28

27.2 / 0.25

27.1 / 0.25

25.1 / 0.23

24.7 / 0.22

23.9 / 0.22

Temporal lobe

105.5 / 0.96

46.7 / 0.42

30.9 / 0.28

26.6 / 0.24

26.9 / 0.24

25.2 / 0.23

24.8 / 0.23

24.6 / 0.22

Parietal lobe

105.2 / 0.95

47.0 / 0.43

31.0 / 0.28

26.7 / 0.24

26.6 / 0.24

25.2 / 0.23

24.7 / 0.22

24.3 / 0.22

Frontal lobe

106.0 / 0.96

47.3 / 0.43

30.9 / 0.28

27.0 / 0.25

26.5 / 0.24

25.5 / 0.23

24.2 / 0.22

24.4 / 0.22

Occipital lobe

105.7 / 0.96

46.9 / 0.43

31.6 / 0.29

26.2 / 0.24

26.6 / 0.24

25.2 / 0.23

24.7 / 0.22

24.6 / 0.22

  1. Each cell contains original R s T value and R s T divided by maximum of R s T along all structures all genes, separated by a slash.
  2. * target genes involved in "apoptotic process" GO category
  3. ** R a l l T