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Table 1 Homo sapiens denisova miRNAs that differ from Homo sapiens sapiens miRNAs.

From: The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain

     Genome position (hg 19)    
# miRNA* Ancestral state (h: human, d: Denisovan) Difference (human/ Denisovan)** Chromosome Position Strand DB SNP ID Allele frequency
(1000 genomes [28])
African population frequency
(1000 genomes [28]or dbSNP 141 [29])
Homo sapiens denisova miRNA mutations common to previously observed human miRNA polymorphisms
1 {hsa-mir-1178} d {A/G} 12 120151493 - rs7311975 C:0.1382 0.4191
2 {hsa-mir-1252} d {A/G} 12 79813049 + rs115256251 G:0.0032 0.0098
3 {hsa-mir-1269a} d {G/A} 4 67142620 + rs73239138 A: 0.3942 0.7277
4 {hsa-mir-146a} d {C/G} 5 159912418 + rs2910164 C:0.3815 0.475(YRI)
5 {hsa-mir-2682 (3p)} d {G/A} 1 98510847 - rs74904371 T:0.0208 0.0053
6 {hsa-mir-3161} d {-/A} 11 48118347 + rs11382316 A:0.7599 +(BUSHMAN)
7 {hsa-mir-4804 (5p)} d {C/G} 5 72174432 + rs266435 G: 0.8001 0.7269
8 {hsa-mir-608} d {C/G} 10 102734778 + rs4919510 G:0.3638 0.4402
   h A/G 10 102734813 + - - -
9 hsa-mir-3124 (3p) d C/A 1 249120631 + rs115160731 A:0.0128 0.0469
10 hsa-mir-4514 h T/C 15 81289798 - rs116034786 G:0.0136 0.0371
11 hsa-mir-1269b h C/(G|C) 17 12820646 - rs7210937 C:0.3520 0.5976
12 hsa-mir-6085 h A/- 15 62635322 + rs372168584 -:0.0006 0.0023
13 hsa-mir-378e d T/C 5 169455502 + rs367764573 C:0.0026 0.0008
   h T/C 5 169455551 + rs376752141 C:0.0026 0.0008
14 hsa-mir-662 h T/A 16 820215 + rs74656628 A:0.1374 0.3971
   h G/A 16 820249 + rs9745376 A:0.0543 0.1921
15 hsa-mir-4463 d -/AG 6 76138146 + rs5877455 AG:0.7079 0.9198
16 {hsa-mir-532
(3p, 5p)}
d {A/G} X 49767832 + rs456615 G:1 0.7587
17   d {A/G} X 49767835 + rs456617 G:1 0.7587
18 {hsa-mir-943} h A/G 4 1988176 - rs368905227 T: 0.0004 0
   d {-/AG} 4 1988188 - rs3034718 CT: 0.2766 0.4629
   d {A/G} 4 1988193 - rs1077020 C: 0.2504 0.3865
Homo sapiens denisova-specific mutations
1 hsa-mir-1321 h G/T X 85090839 + - -  
2 hsa-mir-1909 h G/C 19 1816168 - - -  
3 hsa-mir-3143 h T/C 6 27115417 + - -  
4 hsa-mir-3152 (5p) h A/- 9 18573332 + - -  
5 hsa-mir-3185 h G/A 17 46801808 - - -  
6 hsa-mir-4478 h T/A 9 124882437 - - -  
7 hsa-mir-4700 (3p) h C/T 12 121161049 + - -  
8 hsa-mir-4710 h T/C 14 105144064 - - -  
9 hsa-mir-5687 h C/T 5 54804702 - rs545080149 A:0.0002 0.0008
10 hsa-mir-609 h G/A 10 105978625 - - -  
11 {hsa-mir-671 (3p)} h {C/T} 7 150935593 + - -  
  1. * bold - expression in the central neural system (miRGator 3.0 data [13] and data from [14]), underline - common between H. s. d. and H. s. n.
  2. ** bold - location in mature miRNA, {} common between H. s. d. and H. s. n., italic - location in canonical seed (nucleotides 2-7) region, based on [40]