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Table 2 Homo sapiens neanderthalensis miRNAs that differ from Homo sapiens sapiens miRNAs.

From: The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain

     Genome position (hg 19)    
# miRNA* Ancestral state (h: human, n: Neanderthal; c: chimpanzee) Mutation (human/ Neanderthal)** Chromosome Position Strand DB SNP ID Allele frequency
(1000 genomes [28])
African population frequency
(1000 genomes [28]or dbSNP 141 [29])
Homo sapiens neanderthalensis miRNA mutations common to previously observed human miRNA polymorphisms
1 {hsa-mir-1178} n {A/G} 12 120151493 - rs7311975 C:0.1382 0.4191
2 {hsa-mir-1252} n {A/G} 12 79813049 + rs115256251 G:0.0032 0.0098
3 {hsa-mir-1269a} n {G/A} 4 67142620 + rs73239138 A:0.3942 0.7277
4 {hsa-mir-146a} n {C/G} 5 159912418 + rs2910164 C:0.3815 0.475(YRI)
5 {hsa-mir-2682 (3p)} n {G/A} 1 98510847 - rs74904371 T:0.0208 0.0053
6 {hsa-mir-3161} n {-/A} 11 48118347 + rs11382316 A:0.7599 +(BUSHMAN)
7 {hsa-mir-4804 (5p)} n {C/G} 5 72174432 + rs266435 G:0.8001 0.7269
8 {hsa-mir-608} n {C/G} 10 102734778 + rs4919510 G:0.3638 0.4402
9 hsa-mir-1343 n T/C 11 34963416 + rs2986407 C:0.7668 0.792
10 hsa-mir-3129 (5p) h G/C 2 189997816 - rs192364638 C:1 1
11 hsa-mir-4274 n -/CAC 4 7461827 + rs35245133 CAC:0.858 +(BUSHMAN)
12 hsa-mir-4293 h C/G 10 14425221 - rs12220909 G:0.9619 0.9992
13 hsa-mir-5189 n G/C 16 88535400 + rs80296158 C:0.0507 0.1831
14 hsa-mir-149
(3p, 5p)
n A/G 2 241395500 + rs71428439 G:0.1440 0.1112
15   n T/C 2 241395503 + rs2292832 C:0.3866 0.2716
16 hsa-mir-1908 n A/G 11 61582708 - rs174561 C:0.2796 0.0197
   h G/A 11 61582709 - - - -
17 hsa-mir-3938 n TT/- 3 55886573 - rs10575780 -:0.2426 0.4667
18 hsa-mir-4463 n -/AG 6 76138146 + rs398110299 AG:0.7079 0.9198
19 hsa-mir-4719 n T/C 16 76902847 + rs7500280 C:0.3293 0,2171
   n G/A 16 76902850 + rs7499278 A:0.7528 0.9455
20 {hsa-mir-532}
{(3p, 5p)}
n {A/G} X 49767832 + rs456615 G:1 0.7587
21   n {A/G} X 49767835 + rs456617 G:1 0.7587
22 {hsa-mir-943} n {-/GA} 4 1988188 - rs3034718 CT:0.2766 0.4629
   n {A/G} 4 1988193 - rs1077020 C:0.2504 0.3865
Homo sapiens neanderthalensis-specific mutations
1 hsa-mir-1208 h T/C 8 129162377 + - -  
2 hsa-mir-4532 h C/T 20 56470458 + - -  
3 hsa-mir-4718 h C/T 16 12814185 + - -  
4 hsa-mir-615 h C/T 12 54427811 + - -  
5 hsa-mir-639 h T/C 19 14640435 + rs561305115 C:0.0064 0.004
   h G/C 19 14640399 + rs372602559 C:0.0062 0.004
6 {hsa-mir-671 (3p)} h {C/T} 7 150935593 + - -  
7 hsa-mir-6715b (3p) h G/T 10 114059393 - rs182337914 A:0.0012 0
8 hsa-mir-4749 (3p) h C/(C|T) 19 50357891 + rs372882504 - 1(C)
9 hsa-mir-3939 h(A)/c(G) A/(G|A) 6 167411298 - rs80032204 - 0.915(A)
   h(A)/c(G) A/(G|A) 6 167411300 - rs77840042 - 0.912(A)
   h(C)/c(T) C/(C|T) 6 167411301 - rs75692943 - 0.912(C)
   h G/(G|A) 6 167411334 - rs75823810 - 0.954(G)
   h C/(C|T) 6 167411337 - rs73024232 - 0.957(C)
   h C/(C|T) 6 167411362 - rs77072520 - 0.972(C)
  1. * bold - expression in the central neural system (MiRGator 3.0 data [13] and data from [14])
  2. ** bold - location in mature miRNA, {} - common between H. s. d. and for H. s. n., italic - location in canonical seed (nucleotides 2-7) region, based on [40]