Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships

Table 2 The target mRNAs and their rules for each miRNA rule.

Rule ID	Euclidean distance	Average AUC	#mRNA in dataset	Class¹	#rules² in HCV+	#rules³ in HCV-	#mRNAs in all rules	#mRNAs⁴ in top rules
R1	4.8946	0.9323	300	HCV+	2	14	110	15
R2	3.2888	0.9323	517	HCV+	2	21	159	12
R3	2.5160	0.9323	329	HCV+	2	14	85	12
R4	2.3360	0.8889	247	HCV+	2	11	75	12
R5	0.2256	0.8681	184	HCV+	2	5	41	13
R6	1.6425	0.9115	650	HCV-	8	34	269	10
R7	1.2757	0.8750	398	HCV-	7	28	227	10
R8	2.6420	0.9028	186	HCV-	2	6	55	20
R9	0.9806	0.8958	289	HCV-	1	12	97	11

R1: miR-557 and miR-214; R2: miR-34a and miR-214; R3: miR-493-3p and miR-214; R4: miR-214 and miR184; R5: miR-184 and miR-210; R6: miR-129 and miR-765; R7: miR-765 and miR-210; R8: miR-210 and miR-452; R9: miR-452 and miR-17-3p. ¹ : the miRNA rule defines a region covering all samples of a class.
²(³): the number of mRNA rules, each of which defines a region covering all samples of HCV+(HCV-).
⁴: the number of mRNAs in the top four mRNA rules: the top two mRNA rules in HCV+ (one rule is used if it is the only mRNA rule in HCV+) and another top two rules in HCV-.

ISSN: 1471-2164