Figure 4From: Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profilingDNmiRs regulatory network. This network involves 531 interactions between 11 DNmiRs and 295 DEGs. Six of the 17 DNmiRs did not have known validated targets (Table 2). The regulator hub-DNmiR is miR-17-5p which has 115 target genes (Table S3.1). Up-regulated Trp53inp1 being targeted by 7 DNmiRs (Table S3.2) is the miRNA target hub. The background of hub-miRNAs/genes is marked in purple. The V-shaped nodes correspond to the miRNAs, while the rectangle-shaped nodes are the target genes, the nodes marked by the blue border represent the co-miR-122 targets, and the octagonal nodes represent the transcription factors (TF). The up-regulated miRNAs/genes are marked in red; down-regulated miRNAs/genes are marked in green. Regulatory effects are illustrated as blunt ends (⊥) between miRNAs and genes.Back to article page