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Figure 4 | BMC Genomics

Figure 4

From: Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling

Figure 4

DNmiRs regulatory network. This network involves 531 interactions between 11 DNmiRs and 295 DEGs. Six of the 17 DNmiRs did not have known validated targets (Table 2). The regulator hub-DNmiR is miR-17-5p which has 115 target genes (Table S3.1). Up-regulated Trp53inp1 being targeted by 7 DNmiRs (Table S3.2) is the miRNA target hub. The background of hub-miRNAs/genes is marked in purple. The V-shaped nodes correspond to the miRNAs, while the rectangle-shaped nodes are the target genes, the nodes marked by the blue border represent the co-miR-122 targets, and the octagonal nodes represent the transcription factors (TF). The up-regulated miRNAs/genes are marked in red; down-regulated miRNAs/genes are marked in green. Regulatory effects are illustrated as blunt ends () between miRNAs and genes.

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