Figure 1

Examples of long K27HMD regions in the medaka genome. Examples of K27HMD regions enclosed in dashed boxes. Each screen capture shows an image in a medaka genome browser that displays tracks of gene structures, CpG methylation levels observed by bisulfite sequencing, and levels of H3K27me3 and H3K4me2 in blastula cells (half-day embryos). A. A K27HMD region of length ~4 kbp with cbx4, and a ~8 kbp region with cbx8. B. A large region of length ~90 kbp with hoxa genes. C. A ~6 kbp region with six2, and a ~14 kbp region with hnf6. D. A ~20 kbp region with zic1 and zic4.