Length distribution of large K27HMD regions in the medaka genome. A-B. Comparison between CSMinfinder (minimum length threshold of 4 kbp), ChromHMM, and Nakamura's method. The x-axis shows the minimum length of K27HMD regions, and the y-axis shows the accumulated number of K27HMD regions longer than or equal to the threshold in the x-axis. Because of the space limitations, the histogram is divided into two sub-histograms A (threshold is ≤ 10 kbp) and B (threshold ≥ 11 kbp). C. In this case, we set the minimum threshold to 8 kbp using CSMinfinder.