Examples of large K27HMD regions around developmental genes in the human genome. A. The figure displays several K27HMD regions in the human chromosome 11 around pax6, a gene that regulates eye and brain development. CSMinfinder and Nakamura's method detected large K27HMD regions of >4 kbp in size and output large regions that largely overlapped; however, ChromHMM divided these regions into smaller ones. B. These large K27HMD on human chromosome 7 were located around a cluster of hox genes that regulate the body plan of the head-tail axis. ChromHMM yielded much smaller K27HMD regions as output than did the other two methods.