Figure 4
From: HEPeak: an HMM-based exome peak-finding package for RNA epigenome sequencing data
Simulation results illustrate HEPeak performs better than ExomePeak. A. The ROC curve of HEPeak and exomePeak. B. An example of a simulated gene loci, where there are 10 positive and 90 negative peaks. The top panel depicts the simulated read counts and the bottom panel shows the predicted results of HEPeak and exomePeak. exomePeak detects 8 of 10 true positives, with false positive rate 7.78%; while HEPEAK achieved the same sensitivity but made much fewer false positives at about 1.11%.