Gene network modules of TF-gene interactions. (a) Topological overlap matrix (TOM) heatmap corresponding to the ten co-expression modules. Each row and column of the heatmap represent a single gene. Spots with bright colors denote weak interaction whereas darker colors denote strong interaction. The dendrograms on the upper and left sides show the hierarchical clustering tree of genes. (b), (c), and (d) are the final GRN networks highlighting the identified key drivers genes for the green, magenta, and red modules, respectively. Square nodes denote the identified driver genes that are targeted by drugs. Networks were visualized using the Igraph package in R.