Figure 4

Proximity analysis of the somatic mutations with the dysregulated miRNAs and differentially methylated genes. Ideogram plots showing the genomic distribution for (a) the 21 cases of deregulated miRNAs adjacent to somatic mutations. The outer green circle shows the entire dataset of miRNAs, whereas the next highlighted red lines refer to the adjacent deregulated miRNAs (20 miRNAs where one miRNA is matched to 2 SNVs). The inner blue circle represent the entire set of somatic SNVs and the next highlighted red lines depict the SNVs matched to the 21 cases. (b) The 347 cases of somatic mutations occurring in the promoter regions of differentially methylated genes. The outer green circle shows the entire set of differentially methylated genes, whereas the next highlighted red lines refer to the identified cases adjacent to the somatic mutations. The inner blue circle represents the entire set of somatic SNVs and the next highlighted red lines depict the SNVs matched to the identified cases. The plot illustrates also the fractions of the three considered types of mutations (C->T, C->G and C->A) showing the occurrence frequency for each one.