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Figure 5 | BMC Genomics

Figure 5

From: Analyse multiple disease subtypes and build associated gene networks using genome-wide expression profiles

Figure 5

Gene network obtained for AML with the RNA-seq dataset. The network contains the top-30 ranked genes selected after running geNetClasifier to analyse the RNA-Seq expression data of normal karyoptype AML (nk-AML) versus AML with t(15;17) (APL) samples. The network shows two clear clusters: one including genes that are up-regulated in nk-AML and another with down-regulated genes. The red cluster includes many homeobox (HOX) genes highly correlated. These genes are characteristic of nk-AMLs and show good agreement with the results obtained with microarrays in spite of being two totally independent datasets.

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BMC Genomics

ISSN: 1471-2164

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