TY - JOUR AU - Bansal, Mukesh AU - Mendiratta, Geetu AU - Anand, Santosh AU - Kushwaha, Ritu AU - Kim, Ryan Hyunjae AU - Kustagi, Manju AU - Iyer, Archana AU - Chaganti, Raju SK AU - Califano, Andrea AU - Sumazin, Pavel PY - 2015 DA - 2015/05/26 TI - Direct ChIP-Seq significance analysis improves target prediction JO - BMC Genomics SP - S4 VL - 16 IS - 5 AB - Chromatin immunoprecipitation followed by sequencing of protein-bound DNA fragments (ChIP-Seq) is an effective high-throughput methodology for the identification of context specific DNA fragments that are bound by specific proteins in vivo. Despite significant progress in the bioinformatics analysis of this genome-scale data, a number of challenges remain as technology-dependent biases, including variable target accessibility and mappability, sequence-dependent variability, and non-specific binding affinity must be accounted for. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-16-S5-S4 DO - 10.1186/1471-2164-16-S5-S4 ID - Bansal2015 ER -