Figure 3

Distribution of ChIP-seq tag density and differential binding affinity ( dbA ) for predicted type I and type II TF binding sites. By random drawing 25% of all called ChIP-seq peaks ten times, meta-PBEMs of human ESR1 and SPIB were estimated, respectively, by a parallel ensemble version of BayesPI2+. Expected P-values, dbA, and classification of type I and type II TF binding for all called peaks were based on these meta-PBEMs. In the figure, left and right panels illustrate distributions of log normalized ChIP-seq tag density and dbA of predicted type I (red lines) and type II TF binding sites (blue lines) for ESR1 and SPIB, respectively.