Figure 6From: Comprehensive genome-wide transcription factor analysis reveals that a combination of high affinity and low affinity DNA binding is needed for human gene regulationDifferential histone modifications at three types of putative ESR1 target genes. A two-tailed t-test was used to evaluate significance of various marks between ESR1 target genes (i.e. 'C', 'B', and 'A' genes) and the rest of genes in genome. Positive and negative T-values are colored by red and green in the figure, where 0, +1 and −1 represent histone modifications in E2 treated MCF-7 breast cancer cell lines at gene body, 5 kb upstream and 5 kb downstream, respectively.Back to article page