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Table 1 List of the 10 candidate modulator genes.

From: Co-modulation analysis of gene regulation in breast cancer reveals complex interplay between ESR1 and ERBB2 genes

Gene symbol

Entrez gene name

Locationa

Typea

ADAM12

ADAM metallopeptidase domain 12

Plasma Membrane

peptidase

CCL5

chemokine (C-C motif) ligand 5

Extracellular Space

cytokine

ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Plasma Membrane

kinase

ESR1

estrogen receptor 1

Nucleus

ligand-dependent nuclear receptor

IGF1

insulin-like growth factor 1 (somatomedin C)

Extracellular Space

growth factor

MIF

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Extracellular Space

cytokine

MKI67

marker of proliferation Ki-67

Nucleus

other

MYC

v-myc avian myelocytomatosis viral oncogene homolog

Nucleus

transcription regulator

RECK

reversion-inducing-cysteine-rich protein with kazal motifs

Plasma Membrane

other

TP53

tumor protein p53

Nucleus

transcription regulator

  1. a Gene information was obtained from Ingenuity Pathway Analysis (Qiagen Inc.).