Table 3 Top 3 clusters of enriched GO molecular functions and biological processes in ESR1 modulated genes.
GO ID | GO term | Number of genes | P-valuea |
|---|---|---|---|
Cluster 1 (Enrichment Score: 4.23) | |||
GO:0006259 | DNA metabolic process | 54 | 7.85 × 10-6 |
GO:0033554 | Cellular response to stress | 55 | 8.80 × 10-5 |
GO:0006974 | Response to DNA damage stimulus | 40 | 1.32 × 10-4 |
GO:0006281 | DNA repair | 33 | 1.33 × 10-4 |
Cluster 2 (Enrichment Score: 3.95) | |||
GO:0042802 | Identical protein binding | 61 | 4.33 × 10-5 |
GO:0046983 | Protein dimerization activity | 52 | 1.48 × 10-4 |
GO:0042803 | Protein homodimerization activity | 36 | 2.21 × 10-4 |
Cluster 3 (Enrichment Score: 3.66) | |||
GO:0043627 | Response to estrogen stimulus | 19 | 1.98 × 10-5 |
GO:0010033 | Response to organic substance | 68 | 2.90 × 10-5 |
GO:0048545 | Response to steroid hormone stimulus | 26 | 7.27 × 10-5 |
GO:0009725 | Response to hormone stimulus | 38 | 3.94 × 10-4 |
GO:0009719 | Response to endogenous stimulus | 40 | 6.91 × 10-4 |
GO:0032355 | Response to estradiol stimulus | 9 | 0.010 |