Table 4 Top 3 clusters of enriched GO molecular functions and biological processes in ESR1−ERBB2 co-modulated genes.
GO ID | GO term | Number of genes | P-valuea |
|---|---|---|---|
Cluster 1 (Enrichment Score: 2.22) | |||
GO:0009725 | Response to hormone stimulus | 11 | 6.49 × -04 |
GO:0009719 | Response to endogenous stimulus | 11 | 0.001 |
GO:0048545 | Response to steroid hormone stimulus | 7 | 0.004 |
GO:0010033 | Response to organic substance | 14 | 0.004 |
GO:0043434 | Response to peptide hormone stimulus | 6 | 0.008 |
GO:0032868 | Response to insulin stimulus | 4 | 0.045 |
GO:0043627 | Response to estrogen stimulus | 4 | 0.051 |
Cluster 2 (Enrichment Score: 1.92) | |||
GO:0055114 | Oxidation reduction | 14 | 0.002 |
GO:0048037 | Cofactor binding | 7 | 0.012 |
GO:0050662 | Coenzyme binding | 6 | 0.012 |
GO:0009055 | Electron carrier activity | 5 | 0.089 |
Cluster 3 (Enrichment Score: 1.83) | |||
GO:0046983 | Protein dimerization activity | 11 | 0.008 |
GO:0042802 | Identical protein binding | 12 | 0.009 |
GO:0042803 | Protein homodimerization activity | 7 | 0.042 |