TSG-OCG network. Node color indicates the different protein sets: red for TSG proteins, blue for OCG proteins, and green for linkers that could link TSG proteins and OCG proteins. Edge color indicates protein-protein interaction among different protein sets: red for the interactions among TSG proteins, blue for the interactions among OCG proteins, dark green for the interactions between TSG proteins and OCG proteins, and gray for the interactions between linkers and OCG proteins or TSG proteins. Node size is corresponds to the mutation frequency in Pan-Cancer samples. The larger the node, the higher the frequency was.