Table 4 Pathways prioritized over 50% in rank.
Pathway | Potential association with malaria |
|---|---|
REACTOME PYRUVATE METABOLISM | Pyruvate kinase deficiency protect against malaria [77] |
REACTOME BASIGIN INTERACTIONS | Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum [67] |
PID SYNDECAN1 PATHWAY | Induced by parasite infection [78] |
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Pyruvate kinase deficiency protect against malaria [77] and citric acid cycle activity involves chloroquine resistance [79] |
REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Associated with Plasmodium induced thrombocytopenia [80] |
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Associated with red blood cell adhesion to the endothelial cell and cerebral malaria [81, 82] |
BIOCARTA VDR PATHWAY | Control cellular nutrient uptake, differentiation, apoptosis, which may be affected by parasites [13, 83] |
BIOCARTA MONOCYTE PATHWAY | Recruitment and activation of monocytes and macrophages are essential for both protection and pathology in malaria-infected individuals [84] |
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Platelet adhesion and aggregation may play important roles in facilitating adhesion of infected red blood cells [85–87] |