Figure 1From: Better prediction of functional effects for sequence variantsSNAP2 performs best for the ALL data set. This figure shows performance estimates for the ALL data set. Our new method SNAP2 (dark blue, AUC = 0.905) outperforms its predecessor SNAP (light blue, AUC = 0.880), PolyPhen-2 (orange, AUC = 0.853) and SIFT (green, AUC = 0.838) over the entire spectrum of the Receiver Operating Characteristic (ROC) curve. Curves are significantly different from each other at a significance level of P < 10-4 as measured by the DeLong method [59]. All SNAP2 results were computed on the test sets not used in training after a rigorous split into training, cross-training and testing. Results for PolyPhen-2 and our original SNAP included some of those proteins in their training, suggesting over-estimated performance.Back to article page