Table 3 Number of loci in each category of disease relevance for each mechanism
From: Insights from GWAS: emerging landscape of mechanisms underlying complex trait disease
Locus category | #Loci with at least 1 low impact missense mechanism | #Loci with at least 1 high impact missense mechanism | #Loci with at least 1 change in expression mechanism | #Loci with at least 1 putative splicing mechanism | #Loci with at least 1 direct splice mechanism |
|---|---|---|---|---|---|
A | 2 | 3 | 21 | 3 | 2 |
B | 84 | 75 | 101 | 71 | 15 |
C | 39 | 32 | 32 | 48 | 13 |
D | 1 | 8 | 9 | 9 | 6 |