Figure 2

Selecting features for OG and TSG prediction. A) Box plots illustrate feature differences between OGs (red), TSGs (blue) and NGs (gray). Associated p-values on the top of each box plot are based on one-tailed Mann-Whitney U tests and reflect the differences between OGs and NGs, and TSGs and NGs. B) Dots reflect the frequencies of protein altering mutations in the combined set of tumors from seven cancer types. OGs (red), TSGs (blue) and NGs (gray) are sorted alphabetically on the x-axis. C) Proportions of loss of function (LOF) to benign mutations are plotted against the entropy based mutation selection scores for all human genes. Blue indicates high fractions of LOF mutations, while red indicates high mutation selection. D) Stacked bar plots present the relative frequencies of mutation classes in the combined tumor panel for OGs, TSGs and NGs.