Figure 7
Quantitative mass spectrometry based proteomic analysis after EZH2 inhibition. A) Protein expression differences of selected cell cycle regulators in EPZ-6438 (Epizyme®, Cambridge, MA) versus DMSO treated lymphoma cells (WSU-DLCL2) are represented as log2 ratios. B) Global protein expression changes after 8 days of EPZ-6438 treatment. Down-regulated cell cycle regulators are highlighted in dark blue.