Analysis of recurrent somatic mutations by cancer types (red) and all cancers together (blue). Plots A and B represent the complementary cumulative distributions (CCD) of the fraction of somatic mutations and affected donors respectively. They are calculated using an increasing level of mutation recurrence, which is defined as the number of times a somatic mutation is observed in different donors. In Panel C, is plotted the CCD of the fraction of affected donors as a function of the fraction of somatic variants. The curve is obtained considering an increasing threshold of mutation recurrence (Section 2 in Additional file 1).