NPM3 genomic structure and linkage to FGF8. (A) Genomic structure of NPM3. Boxed areas represent NPM3 exons. The yellow and black shadings represent translated and untranslated regions, respectively. (B) Linkage of NPM3 to FGF8. The location of genes and restriction map were determined by a combination of sequencing and restriction mapping of lambda clones and subclones in this study and a previous study []. An NPM3 cDNA probe will hybridize to restriction fragments of the following sizes in human genomic DNA: Avr II, 0.4 and 3.9 kb; Bam H I, 1.6 and 6.0 kb; Eco R V, 7.2 kb; Hind III, 6.8 kb; Kpn I, 6.6 kb; Sac I, 1.6 and 4.0 kb; Sma I, 1.0 and 5.1 kb; Stu I, 2.6 and 14.1 kb;Xho I, 8.4 kb. Restriction enzyme abbreviations: A, Avr II; B, Bam H I; H, Hind III; K, Kpn I; RV, Eco R V; N, Not I; S, Sac I; Sm, Sma I; St, Stu I; Xh, Xho I.