Comparison and features of human NPM3 and mouse Npm3 amino acid sequences. Identical amino acids are denoted by an asterisk, highly similar residues by a colon and less similar residues by a period, as determined by CLUSTAL W software. The putative nuclear localization signal is overlined. Potential phosphorylation sites in NPM3 for the indicated kinases are shown, as predicted by NetPhos 2.0. Arrows denote splice points in the mRNA. Dashes represent gaps in the alignment. Kinase abbreviations: CKI, casein kinase I; CKII, casein kinase II; CaMII, calmodulin-dependent protein kinase II; GSK3, glycogen synthase kinase 3; PKA, protein kinase A; PKC, protein kinase C.