Figure 3

Alignment of the leucine-rich repeats of the human, murine, drosophila, caenorhabditis and yeast CCR4 family proteins. The consensus shown above is that of the "S.cerevisae adenylate cyclase" class of 23-amino acid long, proline-containing leucine-rich repeats, which includes the yCCR4 LRR [28]. Conserved or aliphatic residues matching the consensus sequence are boxed or circled, respectively, a denotes an aliphatic residue.