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Figure 3 | BMC Genomics

Figure 3

From: GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors

Figure 3

Phylogenetic analysis of human nucleotide GPRs. (A) Phylogenetic tree. The two nucleotide-receptor subgroups "a" and "b" and the related non-nucleotide receptors (n) are indicated. Chromosomal localizations and known endogenous ligands with highest affinities (in brackets) are indicated for each GPR. Phylogenetic analysis assigned a support value of at least 53% to each internal branch. (B) Alignment of putative nucleotide-binding motifs at the beginning of transmembrane domain seven. The proline-containing motif towards the end of transmembrane domain seven is indicated below the alignment. The accession numbers of the receptors are: GPR86, AAK01864; GPR87, AAK01858; GPR91, AF348078; H963, AAC51846; KIAA0001, BAA02791; P2Y1, CAA07339; P2Y2, XP_006367; P2Y4, P51582; P2Y5, P43657; P2Y6, Q15077; P2Y7, Q15722; P2Y9, Q99677; P2Y10, AAB57836; P2Y11, AAB88674; P2Y12, AAG48944. (C) Schematic diagram of the subgroup "a" gene cluster on chromosome 3q24. In the upper part the overlapping BAC clones, coding for the receptors indicated below, are given. The genes of P2Y12, GPR86, and GPR87 are located in a head-to-tail configuration within a distance of 46.5 kb on one contig of AC024886. The GPR87 gene is also present on AC078816, which overlaps with AC024886 in 15 kb of its sequence. The H963 gene is encoded by AC078816 and AC011103, the KIAA0001 gene by AC078816, AC011103, and AC063935. From these data the order of the genes can be deduced. Gaps in the known sequence of the BAC clones coding for H963 and KIA0001 make it impossible to determine the orientation and exact size of the intergenic regions.

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