Relationship of H/E(spl)/Hey-related proteins (A) Similarity tree of the different H/E(spl)/Hey-related proteins in Fugu. (B) Similarity tree of the different proteins from Fugu and zebrafish. Identical colours in (A) and (B) indicate similar proteins. Blue green: c-Hairy type, dark green: Her3 similar, green: Her8 similar, light red: Hey similar, orange: Enhancer of split type, violet: Her1/5/7 similar. The conceptually translated proteins of Fugu were named according to the zebrafish homologues. c-Hairy1 class, proteins belonging to the c-Hairy1 similar proteins; c-Hairy2 class, proteins belonging to the c-Hairy2 similar proteins; c-Hairy-related class, proteins similar to c-Hairy1 and 2 building up a novel class of c-Hairy like proteins; Esr, Enhancer of split-related; Her, Hairy and Enhancer of split-related; Hey, Hairy and Enhancer of split-related with YRPW motif; Hey-related, similar to the Hey proteins. Numbering of the Fugu proteins according to the contig in which they were identified (see table 1). Trees were computed making use of the Neighbor-Joining method with a bootstrap support of 100 replicates.