Alignment of the upstream sequences of c-hairy class genes The upstream sequences of the c-hairy1/2 class genes her 6 and her 9 from Danio, Fugu and Tetraodon were aligned with the promoters of x-hairy2a and human hes1. Conservation levels: 75% or more conserved nucleotides are marked in black, 50% or more conserved nucleotides are marked in dark grey and nucleotides conserved to more than 25% are indicated in light grey. Boundaries of SPS, the potential Suppressor of hairless paired site, are indicated by the arrows. Potential CCAAT-boxes, hexamer sequences and TATA-boxes are indicated by a bold bar. 1, upstream sequences belonging to the c-hairy1 class; 2, upstream sequences belonging to the c-hairy2 class; Hex, hexamer sequence; SPS, Suppressor of hairless paired binding site; Dr, Danio rerio; Fr, Fugu rubripes; Hs, Homo sapiens; Tr, Tetraodon nigroviridis; Xl, Xenopus laevis.