Comparison of HMG-box sequences. The HMG-box region of TOX is aligned with the HMG-box motifs found in seven other proteins representing the two major subfamilies of HMG-box proteins. Similarities between the HMG-boxes of both groups of proteins are highlighted in gray and include matches to the consensus HMG-box domain (accession number pf00505) defined in the Pfam protein families' database. Residues in red and purple distinguish these two subgroups of HMG-box proteins and are discussed in the text. In addition, the consensus sequence GXXW (or more rarely AXXW, as also found in TOX) found commonly in HMG-boxes is shown in blue.