Figure 1From: High accuracy genotyping directly from genomic DNA using a rolling circle amplification based assayLigation of OCP to genomic DNA target Open circle probe (OCP) anneals to genomic DNA target, and the 3' base either base pairs with the target (red) or creates a mismatch (blue). The matched OCP is circularized by ligase, and becomes topologically linked to the target.Back to article page