Figure 8
Alignment of human, macaque, mouse and rat 13043 sequences. This alignment was anchored on a single cDNA isolated from macaque (AB0770087). This sequence was compared to the human (Hs), mouse (Mm) and rat (Rn) genomic sequences at Ensembl and individual exons were assigned. One additional potential exon was assigned based on similarity between genomic sequences based on PipMaker analysis. The human and mouse sequences listed here match partially with predicted proteins in both human and mouse (ENSP0000306627 and XP_156183, respectively) but conform more to the template predicted by the macaque sequence. The rat sequence was constructed from genomic sequences AABR02142366, AABR02119574, AABR02127843, AABR02117677 and AABR02097473. Predicted transmembrane domains are underlined in red in the human sequence and a potential nucleotide binding domain is underlined in blue. A putative cation channel in the human, mouse and rat proteins is double underlined in the mouse sequence. The region of similarity to the original hamster clone is indicated with a red dotted underline.