Figure 9

Alignment of human, macaque and mouse 15014 sequences. The sequences of human (Hs), mouse (Mm) and macaque (Mf) 15014 orthologues were compared in Align X. The human sequence was derived from XP_089976 (LOC159989). The mouse sequence was obtained from a combination of XP_134746 (LOC234964), a hypothetical protein predicted from the NCBI annotation process along with additional exons predicted from comparisons between the human cDNA and the mouse genomic sequence. The macaque sequence was obtained from Genbank entry BAB63125. Gaps in the human sequence indicate the likely presence of alternative exo ns that may undergo alternative splicing. This hypothesis was supported by exon mapping in both the mouse and rat genome sequences (data not shown). We were unable to detect additional exons in the mouse genomic sequence that might encode the N-terminal sequences in the human protein sequence. The similarity to the hamster clone is underlined.