Figure 1

Transmission disequilibrium and genetic linkage analyses of the 6p21.3 reading disability locus, regional STR markers and transcription map. At the top of the figure is the result of the DeFries-Fulker linkage (T Score, solid line), and QTDT linkage disequilibrium (chi-square, dashed line) [14]. The location and order of the 29 STRs are shown below which identify a peak of transmission disequilibrium at marker JA04. Below the markers is a detailed representation of 1.2 Mb surrounding marker JA04. The 19 genes and 2 pseudogenes encoded in this region are shown with the telomere on the left and centromere on the right and their position and direction of transcription indicated by the arrows.