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Table 4 Top ten prostate-specific genes identified by integrated PEM scores from Gene Expression Atlas, SAGEmap and TissueInfo.

From: Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases

%PEM a

UniGene cluster

LocusLink symbol

Description and references

95%

Hs.183752

MSMB

beta microseminoprotein; synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma [77]

94%

Hs.1852

ACPP

prostatic acid phosphatase [78]

82%

Hs.171995

KLK3

kallikrein 3; prostate specific antigen (PSA) [79]

73%

Hs.78344

MYH11

smooth muscle-specific myosin heavy polypeptide 11 [80]

70%

Hs.300772

TPM2

tropomyosin 2 (beta); binds actin [81]

55%

Hs.195464

FLNA

filamin A; binds actin [82]

54%

Hs.75777

TAGLN

transgelin; smooth muscle-specific actin binding protein [83]

53%

Hs.262476

AMD1

S-adenosylmethionine decarboxylase 1; key enzyme in the synthesis of seminal polyamines such as spermine, spermidine [84]

53%

Hs.9615

MYL9

myosin, smooth muscle-specific regulatory light polypeptide 9 [85]

48%

Hs.179817

RDH11

androgen-regulated short-chain dehydrogenase/reductase 1 [86]

  1. a Prostate PEMGEAmax = 4.30, PEMSAGEMAPmax = 1.97, and PEMTISSUEINFOmax = 1.61