Table 5 Differential expression of human XRRA1 in XR-treated HCT116 clones, in normal tissues/organs and cells, as well as in various cancer cell types.
Cells/Tissues/Organs | Relative Expression Level (Normalized against G3PDH)* | Cell/Tissue/Organ type; Cancer Type |
|---|---|---|
HCT116Clone2_XRR | +++ | Colorectal, more resistant to X-radiation than HCT116 |
HCT116Clone10 | ++++ | Colorectal, similar radiation response to HCT116 |
HCT116CloneK_XRS | ++++++ | Colorectal, more sensitive to X-radiation than HCT116 |
HCT116Clone2_XRR | +++ | Without X-radiation |
HCT116Clone2_XRR M10 | ++++ | 10 Minutes after X-radiation |
HCT116Clone2_XRR H6 | ++ | 6 Hours after X-radiation |
HCT116Clone2_XRR H24 | + | 24 Hours after X-radiation |
HCT116Clone10 | ++++ | Without X-radiation |
HCT116Clone10 M10 | + | 10 Minutes after X-radiation |
HCT116Clone10 H6 | + | 6 Hours after X-radiation |
HCT116Clone10 H24 | + | 24 Hours after X-radiation |
HCT116CloneK_XRS | ++++++ | Without X-radiation |
HCT116CloneK_XRS M10 | + | 10 Minutes after X-radiation |
HCT116CloneK_XRS H6 | + | 6 Hours after X-radiation |
HCT116CloneK_XRS H24 | ++++ | 24 Hours after X-radiation |
Testis | ++++++++ | Normal |
Prostate | +++++ | Normal |
Ovary | +++++ | Normal |
Leukocyte | ++ | Normal |
Spleen | + | Normal |
Thymus | ++ | Normal |
Small Intestine | ++ | Normal |
Colon | + | Normal |
AG1522 | ++++ | Normal fibroblast (immortalized) |
COS-7 | +++ | Normal fibroblast (immortalized) |
HDMEC | ++++ | Normal microvascular endothelial (primary) |
MCF7 | + | Breast cancer |
MDA MB435 | +++++ | Breast cancer |
U251MG | + | Glioma |
SKMEL-3 | + | Melanoma |
HT144 | + | Melanoma |
HTB56 | +++ | Lung cancer |
A594 | ++++ | Lung cancer |
Daoy | ++++ | Neuroblastoma |
SKNA | +++ | Neuroblastoma |
SHSY | ++++ | Neuroblastoma |
A2780CP | + | Ovarian cancer, resistant to cisplatin |
OCCL | ++++ | Ovarian cancer |
OV2008 | ++++ | Ovarian cancer |
C13 | +++ | Ovarian cancer |
433 | + | Ovarian cancer |
SKOV3 | ++ | Ovarian cancer |
HEY | ++++ | Ovarian cancer |
429 | +++ | Ovarian cancer |
PC-3 | + | Prostate cancer |
DU145 | +++++ | Prostate cancer |
SN12C | + | Renal cancer |
HT29 | + | Colorectal cancer |
K-562 | +++++ | Leukemia |
Mm TM28 | +++ | (Murine) Fibrosarcoma |
Mm FS-TM28 | + | (Murine) Fibrosarcoma biopsy |
Mm ES-R1 | ++ | (Murine) Embryonic Stem Cell |