Multiple sequence alignment of the 7TMR-DISMED1 and accessory domains of sialate 9-O-acetylesterases, β-glucoronidases and β-glucosidases. Multiple sequence alignment the 7TMR-DISMED1 was constructed as detailed in the legend to Figure 1. The PHD-secondary structure  is shown above the alignment with E representing a β strand, and H an α-helix. In addition to the convention described in Fig. 1 the consensus also shows the aliphatic subset of the hydrophobic class (l; ALIVMC, yellow shading) and the aromatic subset of the hydrophobic class (a; FHWY, yellow shading). The families shown to the right are A – 7TMR-DISMED1, B – accessory domains of sialate 9-O-acetylesterases and C – accessory domains of β-glucoronidases and β-glucosidases. The species abbreviations are as shown in Table 1 and Kpne – Klebsiella pneumoniae; Klac – Kluyveromyces lactis; Ldel – Lactobacillus delbrueckii; Lpla – Lactobacillus plantarum; Ssal – Streptococcus salivarius; Tthe – Thermoanaerobacterium thermosulfurigenes; Hsap – Homo sapiens; Mmus – Mus musculus.