The maximum likelihood phylogenetic tree of the AlkB family. Only representative members (from human and E. coli), corresponding to the sequences in Fig. 1 are shown for the clarity of presentation. The position of the root was inferred from the large 2OG-Fe2+ oxygenase superfamily tree (data not shown). The topology of the presented tree received very high p-value support according to the Shimodaira-Hasegawa  and "approximately unbiased"  tests (0.998 and 0.988, respectively).