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Table 2 Drosophila genes differentially regulated in bratk06028neoplastic tissue and their mammalian homologs shown to be involved in cancer formation.

From: Transcriptional signature of an adult brain tumor in Drosophila

Fly gene

Mammalian homolog

Cancertype

CG17498

Hs MAD2L1

breast cancer

CycE

Hs CCNE1

breast cancer

MAPk-Ak2

Hs MAPKAPK2

breast cancer

Ent2

Hs SLC29A1

breast cancer

CG6546

Hs BAF53A

breast cancer

FK506-bp1

Hs FK506-bp1

childhood astrocytoma

cib

Hs TMSB4X

colon cancer

UTPase

Hs DUT

colorectal

Ef1gamma

Hs EEF1G

colorectal adenoma

Aats-ile

Hs IARS

colorectal cancer

msk

Hs IPO7

colorectal cancer

CG8235

Hs SCYE1

fibrosarcoma, melanoma

Bub3

Hs BUB3

gastric cancer

Myb

Mm MYB

glioma

CG5525

Hs CCT4

hepatocelluar and colonic carcinoma

cdc2

Hs CDC2

hepatocellular cancer

Lam

Hs LMNB1

hepatocellular cancer

CG9993

Mm FATP

hepatoma 7288CTC

CG31232

Hs CCNK

Karposi sarcoma

Aats-his

Hs HARS

laryngeal epithelial carcinoma

ash2

Hs ASH2L

leukemia

und

Hs MetAP2

leukemia

GTP-bp

Hs SRPR

leukemia

N

Hs Notch2

lung cancer, leukemia

Dpit47

Hs TTC4

melanoma

nop5

Hs NOP5/NOP58

melanoma

btd

Hs EGR1

melanoma, prostate cancer

Jafrac2

Hs PRDX4

mesothelioma

Nup98

Hs NUP98

myeloid leukemia

Rm62

Hs DDX5

ovarian cancer

fzy

Hs CDC20

pancreatic cancer

mfas

Hs TGFBI

pancreatic cancer

CG15000

Hs NAB1

prostate cancer

Hsp27

Hs HSPB2

prostate cancer

CG8142

Hs RFC4

prostate cancer

ran

Hs RAN

prostate cancer

Ef1alpha48D

Hs EEF1A1

prostate cancer

tll

Mm Nr2f1

retinoblastoma

Ercc1

Hs ERCC1

squamous cell carcinoma of the head and neck

CkIIbeta

Hs CSNK2B

squamous cell carcinoma of the head and neck

GstE1

Hs GSTT1

thyroid cancer

Mipp1

Hs MINPP1

thyroid cancer

CG9344

Hs SNRPF

uterine cancer

RnrS

Hs RRM2

uterine cancer

SmD3

Hs SNRPD3

uterine cancer

Mcm3

Hs MCM3

uterine cervical carcinoma

polo

Hs PLK

various

Cyclin A

Hs CCNA1

various

Mcm2

Hs MCM2

various

Klp61F

Hs KIF11

various

mus209

Hs PCNA

various

CG9772

Hs SKP2

various

Fib

Hs FBL

various

stg

Hs CDC25B

various

CycB

Hs CCNB1

various

Cdk7

Hs CDK7

various

eEF1delta

Hs EEF1D

various

crc

Hs ATF4

various

CG8586

Hs KLKB1

various

betaTub60D

Hs TUBB2

various

BM-40/SPARC

Hs SPARC

various

dm

Hs MYC

various

  1. Drosophila genes differentially regulated in bratk06028neoplastic tissue and their mammalian homologs shown to be involved in cancer formation. Indicated are the Drosophila genes, their human (Homo sapiens, Hs) or mouse (Mus musculus, Mm) homolog, and the cancer type for which misregulation of the mammalian homolog has been reported in available databases like Flybase and PubMed. References are given in the supplementary material (References for table 2) [see Additional file 5].