Figure 2

Flow chart of method used to classify "pathologs". To identify pathologs that correspond to already known mouse orthologs or potential new orthologs, cDNA sequences were compared to known human sequences and conservation of synteny assessed using mouse to human mapping information. If the patholog corresponded to best mouse to human hit the reported function of the gene product was checked. Mouse sequences with reported human ortholog and known function were classified as "known ortholog", sequences reported as best mouse to human hit with unknown function were classified as "ortholog-candidate" and sequences with unknown function that did not correspond to the best mouse to human hit were classified as "novel sequences".