Figure 3

Amino acid and nucleotide sequence view of two insertion regions shared between several mammalian species. Panel A corresponds to an A-insertion found in exon 6 of several species. Panel B corresponds to the GAGV-repeat found in exon 8. Panel C illustrates the synonymous nucleotide differences found in the GAGV-repeat in the cow exon 8. Dots indicate identity with the top sequence. Corresponding amino acids are shown in brackets []. Panel D shows an example of evolutionary scenario that describes the partitions found in exon 8. Tree topology was reconstructed using neighbor-joining method [41] with Jukes-Cantor distance [42], and rooted with rodent sequences. Numbers at the nodes are bootstrap values.