Table 1 Differential Gene Expression in LAPE Cells Relative to LAPN Cells
From: Expression profile of genes regulated by activity of the Na-H exchanger NHE1
Growth Factor/Hormone Signaling | Accession | fold-change |
|---|---|---|
phospholipase C gamma 1 | W65065 | 4.1 |
uPAR | X62701 | 3.5 |
MDK1 (neuronal tyrosine kinase receptor) | X79082 | 3.2 |
FGF-6 | M92416 | 3.1 |
TC21 ras-like protein | W91283 | 3.1 |
tyrosine kinase SEK receptor precursor | W53668 | 3.0 |
GC Binding Protein | Z36270 | 3.0 |
FGFR-4 | X59927 | 2.9 |
casein kinase II alpha | AA153726 | 2.8 |
FYN tyrosine protein kinase | W35964 | 2.6 |
ERK2 | W51403 | 2.5 |
PIP5KII | P48426 | 2.5 |
P2X purinoceptor 3 (ATP receptor) | AA050453 | 2.3 |
IRG47 GTP binding-protein | M63630 | 2.3 |
p120GAP | P09851 | 2.2 |
PDGF/VEGF member | X99572 | 2.1 |
FGF-4 | X14849 | 2.0 |
CAP adenylyl cyclase-associated protein | L12367 | 2.0 |
N-ras | X13664 | 1.9 |
protein-tyrosine phosphatase epsilon precursor | U35368 | 1.7 |
guanine nucleotide binding protein G(K) alpha | W64628 | 1.6 |
brain-derived neurotrophic factor | X55573 | 1.6 |
Grg1 groucho-related gene 1 protein | U61362 | 1.5 |
SOS 2 (ras GEF) | Z11664 | 1.5 |
proteinase activated receptor 2, PAR2 | Z48043 | -1.8 |
receptor of activated protein kinase C (RACK1) | AA024231 | -1.8 |
PAK p21-activated kinase | AA117286 | -2.0 |
guanine nucleotide binding protein gamma-7 | W64628 | -2.1 |
ERF1 EGF-response factor 1 | W33538 | -2.3 |
Fgd1 (faciogenital dysplasis) (Cdc42 GEF) | U22325 | -2.7 |
5-HT5B serotonin receptor | X69867 | -2.7 |
chemokine receptor type 4 | P70658 | -2.7 |
A-raf | AA104043 | -3.4 |
FGF-7 | Z22703 | -3.5 |
GRK5 | W36620 | -3.7 |
Emr1 receptor (EGF-7 TM family) | U66890 | -4.3 |
gliostatin (PD-ECGF) | AA008687 | -5.9 |
MAPKK 3 | W29331 | -8.2 |
Growth and Oncogenesis | Accession | fold-change |
semaphorin E | X85994 | 5.0 |
Evi-1 proto-oncogene | X54989 | 3.1 |
interferon-inducible protein 9–27 | P13164 | 2.5 |
testis-specific c-abl protein | J02995 | 2.5 |
MAF proto-oncogene | W77346 | 2.3 |
MUC18 melanoma-associated antigen | AA088962 | 2.3 |
B94 TNF-α-induced early response gene | L24118 | 2.1 |
calpactin I light chain | M16465 | 2.1 |
Fra 1 | U34245 | 2.0 |
cell division protein FTSH homolog | AA014057 | 1.9 |
ALL-1 zinc finger protein HRX | W62585 | 1.9 |
LAF-4 lymphoid nuclear protein | U34361 | 1.7 |
calpactin I heavy chain | D10024 | 1.6 |
insulin-induced growth response protein CL-6 | AA030483 | 1.5 |
mage-like protein | W51344 | -1.9 |
TRAF4 | X92346 | -2.1 |
rearranged mutant c-myb gene | M13990 | -2.1 |
Ing1 | AF177757 | -2.2 |
Fra 2 | P15408 | -2.8 |
ERV1 | AA034842 | -2.9 |
MAGE-11 | W51344 | -3.4 |
MCF2 Dbl proto-oncogene | W98059 | -4.0 |
HSP 90 alpha | AA117183 | -9.1 |
membrane glycoprotein | Z22552 | -10.7 |
Cell Cycle/DNA Replication | Accession | fold-change |
GADD153 | X67083 | 45.7 |
wee1 kinase | D30743 | 2.3 |
RAD54 DNA-repair gene | X97796 | 1.9 |
14-3-3 protein tau/theta | W61758 | 1.7 |
G1/S-specific cyclin D1 | P25322 | 1.7 |
cell division-associated protein BIMB. | AA165880 | -1.5 |
proliferating-cell nuclear antigen | AA088121 | -1.7 |
CKS-2 cyclin-dep kinases regulatory subunit 2 | X54942 | -1.8 |
GADD45 | AA138777 | -2.1 |
gas1 | X65128 | -2.5 |
SKCDC25 | Q02342 | -4.1 |
FLAP endonuclease-1; FEN-1 | AA072149 | -7.5 |
Cytoskeleton | Accession | fold-change |
clip 170 (restin) | W13214 | 4.2 |
septin 2 (NEDD5 PROTEIN) | W51490 | 3.6 |
KIF4 kinesin-like protein | AA109999 | 3.4 |
neuraxin | AA048974 | 2.1 |
kinesin light chain 1 | W81858 | 2.1 |
axonemal dynein heavy chain | Z83815 | 1.9 |
septin 4 (BRAIN PROTEIN H5) | AA020101 | 1.8 |
gelsolin | J04953 | 1.7 |
myosin regulatory light chain 2, smooth muscle isoform | W18383 | -4.5 |
NF2 neurofibromatosis type 2 isoform I | X74671 | -5.7 |
Cell Adhesion and Extracellular matrix | Accession | fold-change |
mast cell protease 5 precursor | AA032912 | 6.3 |
osteopontin | X51834 | 2.3 |
neural cell adhesion molecule (NCAM-140) | X07233 | 2.1 |
anti-von Willebrand factor antibody NMC-4 kappa chain | U90238 | 2.1 |
inter-alpha-inhibitor H2 | X70392 | 2.0 |
galectin-3 | P16110 | 1.8 |
extensin precursor | W75015 | 1.7 |
E-selectin ligand-1 (ESL-1) | X84037 | -1.6 |
microfibril associated glycoprotein precursor (MAGP) | W08049 | -1.8 |
integrin beta-5 subunit precursor | W14823 | -2.0 |
lectin lambda | U56734 | -3.3 |
type IV collagenase | Z27231 | -26.0 |
Ion Transporters | Accession | fold-change |
CMP-sialic acid transporter | Z71268 | 2.5 |
V-ATPase A | U13837 | 2.2 |
AKR voltage-gated potassium-channel (KCNA4) | U03723 | 2.1 |
potassium channel protein NGK2 | Y07521 | 2.0 |
glucose transporter type 4 insulin-responsive (GT2) | M23383 | -4.0 |
synaptic vesicle amine transporter | AA166512 | -7.1 |
V-ATPase E | W50167 | -10.4 |
Transcriptional Regulation | Accession | fold-change |
histone H3.1 | X16496 | 6.2 |
retinoic acid-binding protein | X51715 | 3.7 |
HNF-3/Forkhead homolog II | Q61575 | 3.2 |
transcription regulatory protein MCP-1 (POU 1) | D13801 | 3.0 |
NfiA2-protein (nuclear factor 1) | Y07691 | 1.8 |
transcription factor C1 | U53925 | -1.5 |
GATA-6 | U51335 | -1.6 |
zinc finger protein 91 | Q05481 | -1.9 |
winged-helix gene, htlf | Y12656 | -2.2 |
C/EBP delta | X61800 | -2.5 |
retinoid X receptor-beta | X66224 | -2.9 |
HLX homeo box protein | X58250 | -3.8 |
Nucleotide Processing | Accession | fold-change |
myoblast cell surface antigen | W98426 | 5.6 |
activator 1 37 KD subunit | W85565 | 3.6 |
RNA polymerase II large subunit | M12130 | 3.0 |
DNA-directed RNA polymerase III largest subunit | W54015 | 3.0 |
uridylate kinase | AA114781 | 1.8 |
U1RNA-associated 70-kDa protein | X15769 | -1.6 |
U6 snRNA-associated protein | W34985 | -3.3 |
Protein Processing | Accession | fold-change |
eukaryotic peptide chain releasing factor GTP-binding subunit | AA105072 | 2.5 |
putative ATP-dependent RNA helicase PL10 | AA125293 | 2.4 |
40S ribosomal protein S10 | W13807 | 2.1 |
tryptophanyl-tRNA synthetase | AA051240 | 1.8 |
ubiquitin carboxyl-terminal hydrolase (protease 4) | W50538 | 1.6 |
ribosomal protein L32 | K02060 | -1.8 |
elongation factor TS (forms complex with EF-tu) | W70475 | -1.9 |
ubiquitin carboxyl-terminal hydrolase (protease 8) | AA087408 | -2.4 |
elongation factor 2 (EF-2) | P05086 | -2.6 |
phenylalanine – tRNA synthetase | AA020069 | -3.8 |
threonyl-tRNA synthetase | AA051240 | -4.5 |
elongation factor TU | AA088054 | -5.4 |
Stress-related | Accession | fold-change |
glutathione peroxidase | AA038094 | 2.9 |
thioredoxin-dependent peroxide reductase 2 | W85659 | 1.6 |
superoxide dismutase 3 (SOD3) | X84940 | -1.5 |
thioredoxin-dependent peroxide reductase 1 | W88176 | -2.1 |
glutathione S-transferase, GSTT1 | X98055 | -3.2 |
24p3 lipocalin | X81627 | -23.7 |
Carbohydrate Metabolism | Accession | fold-change |
pyruvate kinase M2 | AA168931 | 3.8 |
hexokinase | P24049 | 2.4 |
phosphofructose kinase-2 | P70265 | 2.3 |
acetyl-Coenzyme A acetyltransferase 2 | BC000408 | -1.8 |
Ldh-2 | X51905 | -1.9 |
ERV1 | AA034842 | -2.9 |
galactokinase 2 | AA145750 | -2.9 |
citrate transport protein | AA108822 | -2.9 |
phosphorylase B kinase gamma catalytic subunit | AA015461 | -3.7 |
fructose-1,6-bisphosphatase | P19112 | -4.0 |
lactate dehydrogenase | P00338 | -4.0 |
Electron Transport and Oxidative Phosphorylation | Accession | fold-change |
ATP synthase (subunit D) | P31399 | 6.4 |
NADH-ubiquinone oxidoreductase (complex I) | BC002772 | 2.3 |
cytochrome C oxidase VIa | U08439 | 2.2 |
ATP synthase P1precursor (subunit C) | W16250 | 2.0 |
ATP synthase (subunit A) | W49135 | 1.8 |
mitochondrial inner membrane protease subunit 1 | AA009014 | -1.5 |
cytochrome P450IIIA | D26137 | -3.9 |
Trafficking | Accession | fold-change |
beta adaptin | P21851 | 1.9 |
rab10 | AA119194 | 1.5 |
rab8 | P22128 | 3.3 |
rab11b | L26528 | -1.5 |
BRAIN PROTEIN I47(similar to yeast SEC 17) | W55684 | -1.7 |
PROTEIN TRANSPORT PROTEIN SEC22 | AA023107 | -1.8 |
SYNAPTOBREVIN 2 | AA072236 | -4.6 |
Immune-related Signaling | Accession | fold-change |
anti-DNA immunoglobulin heavy chain IgG | U55461 | 3.5 |
immunoglobulin rearranged kappa chain | ET62056 | 3.4 |
complement receptor type 2 precursor (CR2) | W98124 | 2.6 |
thymocyte B cell antigen precursor | AA068606 | 2.3 |
immunoglobulin alpha heavy chain | J00475 | 2.2 |
interferon gamma receptor second chain | U69599 | 1.8 |
pre-B cell enhancing factor precursor | W59723 | 1.8 |
interferon beta type 2 | V00756 | 1.7 |
anti-DNA immunoglobulin light chain IgG | U55604 | 1.6 |
FK506-binding protein precursor (FKBP-13) | AA163272 | -1.5 |
immunoglobulin light chain Fv-fragment | Y10941 | -2.3 |
Ig 1B4.B5 heavy chain mRNA for mouse cytochrome c | ET61726 | -2.3 |
immunoglobulin-like receptor PIRA1 | U96682 | -2.8 |
CD10 neutral endopeptidase (pre-B cell differentiation) | M81591 | -3.1 |
immunoglobulin variable region, heavy chain | X95878 | -3.3 |
immune-responsive gene 1 (Irg1) | L38281 | -3.9 |
anti-DNA immunoglobulin heavy chain IgG | U55550 | -4.1 |
immunoglobulin light chain variable region | ET61272 | -7.8 |
immunoglobulin heavy chain variable region | ET62261 | -8.2 |
Miscellaneous | Accession | fold-change |
parotid secretory protein | X01697 | 4.0 |
amyloid-like protein 1 precursor | Q03157 | 4.0 |
liver receptor homologous protein | M81385 | 1.7 |
oncomodulin | Z48238 | -1.6 |
tctex-1 | M25825 | -1.6 |
beta-hydroxysteroid dehydrogenase type 2 | X90647 | -2.8 |
C57BL/6J ob/ob haptoglobin | M96827 | -2.9 |
angiotensin-converting enzyme | J04947 | -3.2 |
Swiss Webster demilune cell-specific salivary gland protein | W15826 | -7.1 |
neurexophilin 1 | U56651 | -7.8 |