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Table 2 Expression of IGFBP3 and RXRalpha in Prostatic Epithelium

From: Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium

 

Normal Prostate

Nodular Hyperplasia

HGPIN

Prostate Cancer

Metastatic Cancer

IGFBP3

     

Positive cases

105

62

49

202

25

Negative cases

5

1

9

36

8

Statistics (comparison)

 

p = 0.0036 (cancer)

N.S. (cancer)

p = 0.0044 (normal)

N.S. (cancer)

IGFBP3

     

Intensity (avg+/-std)

2.47 +/- 0.70

2.49 +/- 0.65

2.57 +/- 0.82

2.74 +/- 0.56

2.79 +/- 0.49

Percentage cells (avg+/- std)

8.3 +/- 13.5

7.5 +/- 12.5

8.8 +/- 15.2

4.4 +/- 6.6

8.5 +/- 12.6

Nuclear cases

92

59

40

94

8

Cytoplasmic cases

22

6

18

152

11

Statistics (comparison)

 

p < 0.00001 (cancer)

p = 0.065 (cancer)

p < 0.00001 (normal)

N.S. (cancer)

RXRalpha

     

Positive cases

92

58

35

112

16

Negative cases

10

3

31

125

19

Statistics (comparison)

 

p < 0.00001 (cancer)

N.S. (cancer)

p < 0.00001 (normal)

N.S. (cancer)

RXRalpha

     

Intensity (avg+/-std)

2.73 +/- 0.51

2.78 +/- 0.50

2.83 +/- 0.38

2.76 +/- 0.49

3 +/- 0

Percentage cells (avg+/- std)

20.0 +/- 25.5

23.2 +/- 25.7

8.4 +/- 12.5

8.6 +/- 12.6

4.2 +/- 4.6

Nuclear cases

92

58

35

107

16

Cytoplasmic cases

2

0

6

9

0

Statistics (comparison)

 

N.S. (cancer)

N.S. (cancer)

N.S. (normal)

N.S. (cancer)