Figure 5

Genomic alterations specific to stage and MYCN status. Shown is the graphic depiction of the average p-values (P) of genomic alteration of each SW-locus (using a sliding window of 20 adjacent clones) within each tumor subgroup. All possible pair-wise comparisons among the three subgroups for gains or losses (stage 1 vs 4-, 4+ vs 4- and 1 vs. 4+) are shown. The frequency of alteration is estimated by P such that P = 0.15 is equivalent to a frequency of 70% and the lower the P the higher the frequency (details in Methods). Different colors were used to represent different clusters. Magenta: loci common to all groups; cyan: common to 1 and 4-; blue: 1 specific; green: 4- specific; red: 4+ specific, and black: all remaining loci. Colored dots were enlarged for easier visualization.