Alignment of putative protein sequences identifies a ISG12 protein motif. Putative protein product of the genes in Table 1 were aligned using Clustal W  and annotated using Boxshade http://www.ch.embnet.org/software/BOX_form.html. The section of this alignment where the predicted proteins share greatest amino-acid identity is shown. The consensus sequence for this region represents residues that are conserved in 50% or more of the sequences and defines the ISG12 motif (Pfam accession number: PF06140). Black squares represent sequence identity and grey squares represent sequence similarity. Numbers flanking the sequence represent amino-acid numbers in the putative proteins.